H 2 O 2-triggered cleavage of SC-TK-SS31 and ROS-sensitive drug release inside the H 2 O 2-stimulated HK-2 cells. (A) Absorption peaks of SC-TK-SS31 in the presence of 10 mM H 2 O 2 monitored by HPLC at a wavelength of 220 nm. SC-NO-SS31 (irresponsive prodrug) was treated as control. Peaks with an elution time of 4.1 min represent SS31.
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SS-31, also known as elamipretide, is an antioxidant, mitochondria-targeted tetrapeptide.1,2 As a small, water-soluble peptide, SS-31 crosses into the inner mitochondrial membrane to exert activity on cardiolipin, a phospholipid involved in mitochondrial function.1-4 This activity is hypothesized to have wide-ranging potential protective effects — especially regarding …
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,SS-31。 （,Fmoc,,Dmt,Fmoc-Tyr(2,6-Me2,4-tBu)-OH,CAS：1043043-79…
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Adverse neurological effects of short-term sleep deprivation in aging mice are prevented by SS31 peptide (28) "Regulatory proteins for synaptic plasticity were restored, and inflammatory cytokines decreased in the hippocampus of sleep-deprived mice treated with SS31." (28) SS-31 and PE-22-28 Improves Memory and Neuroplasticity.
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(NOTE: If you aren't familiar with why mitochondrial health is important and all the things you can do to optimize it, read this article firstbefore continuing) SS-31 (a.k.a. Elampretide, Bendavia, MPT-141)is a synthetic tetrapeptide (i.e. 4 amino acids long) that was discovered by scientists Hazel H. Szeto and Peter W. Schille…
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In early brain injury (EBI), oxidative stress occurs following subarachnoid hemorrhage (SAH), and mitochondria are intricately linked to this process. SS31, a mitochondria-targeting antioxidative peptide, has been demonstrated to be beneficial for multiple diseases because of its powerful antioxidant and neuroprotective properties. Although our previous …
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The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metabolism reprogramming, are reported to lead to changes in the state of tubular epithelial cells (TECs), and among all the disturbances in metabolism, mitochondria …
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SS-31, a novel mitochondria-targeted peptide, has been proven to provide neuroprotection in a variety of neurological diseases. Its role as a mitochondrial reactive oxygen species (ROS) scavenger and the underlying pathophysiological mechanisms in traumatic brain injury (TBI) are still not well unde …
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SS31 prevented these decrements. Diaphragm-specific force gen-eration averaged 30.2 1.4, 9.4 1.8, 25.5 2.3, and 27.9 0.6 N/cm2 for sham, CLP, sham SS31, and CLP SS31 groups (P 0.001). Similarly, with phrenic nerve stimulation, CLP depressed diaphragm force generation, effects prevented by SS31. During
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In order to verify the hypothesis in the present study, we examined the partition of the conjugates between the blood and the plasma [34].The blood to plasma (B/P) ratio of drugs were determined and the results were shown in Fig. 1 B. After incubation for 60 min at 37 °C, the B/P ratio of SS31 at 50 μM was approximately 1.09, while SS31-DVED-Rapa and SS31–C 9 …
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SC-TK-SS31 was then prepared by conjugating SS31, a mitochondria-targeted antioxidant, to SC via reactive oxygen species (ROS)-sensitive thioketal linker. Because of the effective renal distribution combined with ROS-responsive drug release behavior, the administration of SC-TK-SS31 led to an enhanced therapeutic effect of SS31 by protecting ...
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SS-31, also known as elamipretide, is a member of the Szeto-Schiller (SS) peptide family, meaning it is an aromatic-cationic tetrapeptide that crosses into the inner mitochondrial …
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Barth syndrome (MIM302060, abbreviated BTHS) is a rare, life-threatening, X-linked recessive disease, characterized mainly by infancy or childhood-onset cardiomyopathy, skeletal myopathy ...
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Oxidative stress is implicated in the pathogenesis of ischemia/reperfusion injury. Recently, we demonstrated that activation of CD36, a class B scavenger receptor, mediates free radical production and tissue injury in cerebral ischemia (1). Oxidized low density lipoproteins (oxLDL) are among the ligands that bind to CD36 and are elevated in acute cerebral infarction. SS31 is …
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The aim of this study is to investigate the targeting efficiency of FITC-SS31 to mitochondria in both normal and H 2 O 2-induced oxidative damaged 661W cells, characterizing the properties of FITC-SS31 in the biological assays.The purity and molecular weight of FITC-SS31 were identified using HPLC and MS. MTT and LDH assays were used to evaluate the …
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3 Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, USA. 4 Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA. [email protected].
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We tested the hypothesis that elamipretide plus PTRA would improve renal function, oxygenation, and RBF in patients with atherosclerotic renal artery stenosis undergoing PTRA. Methods and …
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SS31 used in the present study was based on the dosage previ-ously used in protection against myocardial ischemia (22) and in a model of neurodegeneration (27). MeasurementofInfarctVolume Mice were saced 72 h after ischemia. Brains were removed,frozen,andsectioned(thickness,30 m)inacryostat
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Саусгоби сэндс ХХК: Шигшүүр, Бутлуур, Холигч ( sc, jc, mx ) тоног төхөөрөмжийн хэвийн үйл ажиллагааг хангаж, өндөр бүтээмжтэй, аюулгүй ажиллах.
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Dekorativní kameny do akvária Seiryu Stone (Amano Rock), občas nazývané Scenery, patří mezi nejoblíbenější kameny (hardscape) využívané v aquascapingu. Zavolejte nám: +420 739 003 986. ... Seiryu Stone - sada SS31.
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SS31-treated mice received daily subcutaneous (SC) injections (neck and shoulder area) of SS31 (1.5 mg/kg; n = 8), starting at 24 mo of age and continuing until mice reached 28 mo of age (4-month ...
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SS31 repairs the negative changes in oxidative stress, mitochondria function and levels of inflammatory molecules (Escribano-Lopez I, 2018). In the white blood cells of the immune system of T2D patients, SS-31 can reduce oxidative stress, pro-inflammatory signalling and proinflammatory cytokine levels ( Escribano-Lopez I, 2018 ).
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Dietz and Holden (1970) address the Mexico-South America space issue by eliminating the isthmus of Panama, and placing the Yucatan, Honduras, and the Greater Antilles into the space left between North America, Africa, and South America. Although the solution was based on a rather selective conservation of area and geometric convenience, aspects of it …
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Булт бутлуур. Автомат дээж хуваагч. Дээж нунтаглагч. Дээж хуваагч. Бүх төрлийн хэмжээтэй. Шигшүүр шигшигч ...
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